KMID : 0043320150380122216
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Archives of Pharmacal Research 2015 Volume.38 No. 12 p.2216 ~ p.2227
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Anti-diabetic and anti-Alzheimer¡¯s disease activities of Angelica decursiva
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Ali Yousof
Jung Hyun-Ah Choi Jae-Sue
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Abstract
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Diabetes mellitus (DM) and Alzheimer¡¯s disease (AD) constitute two global health issues. DM is an ever-increasing epidemic affecting millions of elderly people worldwide, causing major repercussions on patients¡¯ daily lives, mostly due to chronic complications. Complications from DM can affect the brain, thereby characterizing DM as a risk factor for AD. In the present study, we examined the inhibitory activity of methanol extracts of different parts of 12 Angelica species against ¥á-glucosidase, protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). The methanol extract of Angelicadecursiva exhibited the highest inhibitory activities against ¥á-glucosidase, PTP1B, AChE, and BChE and so was selected for further investigation. Repeated column chromatography based on bioactivity-guided fractionation yielded seven compounds (1?7). Among these compounds, nodakenin (1), nodakenetin (2), umbelliferone (3), cis-3¡Ç-acetyl-4¡Ç-angeloylkhellactone (4), 3¡Ç(R)-O-acetyl-4¡Ç(S)-O-tigloylkhellactone (5), isorutarine (6), and para-hydroxybenzoic acid (7) exhibited potent inhibitory activities against ¥á-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and ¥â-site amyloid precursor protein cleaving enzyme 1 (BACE1). Our results clearly indicate the potential inhibition of ¥á-glucosidase, PTP1B, RLAR, AChE, BChE, and BACE1 by A. decursiva as well as its isolated constituents, which could be further explored to develop therapeutic modalities for the treatment of DM and AD.
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KEYWORD
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Angelicadecursiva, Rat lens aldose reductase, Protein tyrosine phosphatase 1B, Alzheimer¡¯s disease, Cholinesterase, Coumarin
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